7v1a: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v1a OCA], [https://pdbe.org/7v1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v1a RCSB], [https://www.ebi.ac.uk/pdbsum/7v1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v1a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v1a OCA], [https://pdbe.org/7v1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v1a RCSB], [https://www.ebi.ac.uk/pdbsum/7v1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v1a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
<div style="background-color:#fffaf0;">
[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
== Publication Abstract from PubMed ==
Integrins are ubiquitously expressed cell-adhesion proteins. Activation of integrins is triggered by talin through an inside-out signaling pathway, which can be driven by RAP1-interacting adaptor molecule (RIAM) through its interaction with talin at two distinct sites. A helical talin-binding segment (TBS) in RIAM interacts with both sites in talin, leading to integrin activation. The bispecificity inspires a "double-hit" strategy for inhibiting talin-induced integrin activation. We designed an experimental peptidomimetic inhibitor, S-TBS, derived from TBS and containing a molecular staple, which leads to stronger binding to talin and inhibition of talin:integrin interaction. The crystallographic study validates that S-TBS binds to the talin rod through the same interface as TBS. Moreover, the helical S-TBS exhibits excellent cell permeability and effectively suppresses integrin activation in cells in a talin-dependent manner. Our results shed light on a new class of integrin inhibitors and a novel approach to design multi-specific peptidomimetic inhibitors.
 
Inhibition of talin-induced integrin activation by a double-hit stapled peptide.,Gao T, Cho EA, Zhang P, Wu J Structure. 2023 Aug 3;31(8):948-957.e3. doi: 10.1016/j.str.2023.05.016. Epub 2023 , Jun 26. PMID:37369205<ref>PMID:37369205</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7v1a" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Talin 3D structures|Talin 3D structures]]
== References ==
<references/>
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</StructureSection>
</StructureSection>
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