1lj2: Difference between revisions

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[[Image:1lj2.gif|left|200px]]
{{Seed}}
[[Image:1lj2.png|left|200px]]


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{{STRUCTURE_1lj2|  PDB=1lj2  |  SCENE=  }}  
{{STRUCTURE_1lj2|  PDB=1lj2  |  SCENE=  }}  


'''Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization'''
===Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization===




==Overview==
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Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G. Here, we present the X-ray structure of the C-terminal domain of NSP3 (NSP3-C) recognizing a fragment of eIF4GI. Homodimerization of NSP3-C yields a symmetric, elongated, largely alpha-helical structure with two hydrophobic eIF4G binding pockets at the dimer interface. Site-directed mutagenesis and isothermal titration calorimetry documented that NSP3 and PABP use analogous eIF4G recognition strategies, despite marked differences in tertiary structure.
The line below this paragraph, {{ABSTRACT_PUBMED_12086624}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12086624 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12086624}}


==About this Structure==
==About this Structure==
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[[Category: Rotavirus]]
[[Category: Rotavirus]]
[[Category: Translation]]
[[Category: Translation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:58:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:58 2008''
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