1lbd: Difference between revisions
New page: left|200px<br /> <applet load="1lbd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lbd, resolution 2.7Å" /> '''LIGAND-BINDING DOMAI... |
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[[Image:1lbd.gif|left|200px]]<br /> | [[Image:1lbd.gif|left|200px]]<br /><applet load="1lbd" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1lbd, resolution 2.7Å" /> | caption="1lbd, resolution 2.7Å" /> | ||
'''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''<br /> | '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the human retinoid-X receptor RXR-alpha | The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors. | ||
==About this Structure== | ==About this Structure== | ||
1LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Bourguet, W.]] | [[Category: Bourguet, W.]] | ||
[[Category: Moras, D.]] | [[Category: Moras, D.]] | ||
[[Category: SPINE, Structural | [[Category: SPINE, Structural Proteomics in Europe.]] | ||
[[Category: nuclear receptor]] | [[Category: nuclear receptor]] | ||
[[Category: spine]] | [[Category: spine]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:43:25 2008'' | ||
Revision as of 11:43, 21 February 2008
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LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Overview
The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
About this Structure
1LBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:7760929
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