1ll5: Difference between revisions

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[[Image:1ll5.gif|left|200px]]
{{Seed}}
[[Image:1ll5.png|left|200px]]


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{{STRUCTURE_1ll5|  PDB=1ll5  |  SCENE=  }}  
{{STRUCTURE_1ll5|  PDB=1ll5  |  SCENE=  }}  


'''X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem'''
===X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem===




==Overview==
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To determine how imipenem inhibits the class C beta-lactamase AmpC, the X-ray crystal structure of the acyl-enzyme complex was determined to a resolution of 1.80 A. In the complex, the lactam carbonyl oxygen of imipenem has flipped by approximately 180 degrees compared to its expected position; the electrophilic acyl center is thus displaced from the point of hydrolytic attack. This conformation resembles that of imipenem bound to the class A enzyme TEM-1 but is different from that of moxalactam bound to AmpC.
The line below this paragraph, {{ABSTRACT_PUBMED_12435704}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12435704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12435704}}


==About this Structure==
==About this Structure==
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[[Category: Carbapenem]]
[[Category: Carbapenem]]
[[Category: Imipenem]]
[[Category: Imipenem]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:01:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:21:41 2008''
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