1ll8: Difference between revisions

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[[Image:1ll8.gif|left|200px]]
{{Seed}}
[[Image:1ll8.png|left|200px]]


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{{STRUCTURE_1ll8|  PDB=1ll8  |  SCENE=  }}  
{{STRUCTURE_1ll8|  PDB=1ll8  |  SCENE=  }}  


'''Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation'''
===Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation===




==Overview==
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PAS domains are sensory modules in signal-transducing proteins that control responses to various environmental stimuli. To examine how those domains can regulate a eukaryotic kinase, we have studied the structure and binding interactions of the N-terminal PAS domain of human PAS kinase using solution NMR methods. While this domain adopts a characteristic PAS fold, two regions are unusually flexible in solution. One of these serves as a portal that allows small organic compounds to enter into the core of the domain, while the other binds and inhibits the kinase domain within the same protein. Structural and functional analyses of point mutants demonstrate that the compound and ligand binding regions are linked, suggesting that the PAS domain serves as a ligand-regulated switch for this eukaryotic signaling system.
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{{ABSTRACT_PUBMED_12377121}}


==About this Structure==
==About this Structure==
1LL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL8 OCA].  
1LL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL8 OCA].  


==Reference==
==Reference==
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[[Category: Ligand screening]]
[[Category: Ligand screening]]
[[Category: Pas domain]]
[[Category: Pas domain]]
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Revision as of 18:22, 2 July 2008

File:1ll8.png

Template:STRUCTURE 1ll8

Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation

Template:ABSTRACT PUBMED 12377121

About this Structure

1LL8 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation., Amezcua CA, Harper SM, Rutter J, Gardner KH, Structure. 2002 Oct;10(10):1349-61. PMID:12377121

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