1lm8: Difference between revisions

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[[Image:1lm8.gif|left|200px]]
{{Seed}}
[[Image:1lm8.png|left|200px]]


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{{STRUCTURE_1lm8|  PDB=1lm8  |  SCENE=  }}  
{{STRUCTURE_1lm8|  PDB=1lm8  |  SCENE=  }}  


'''Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex'''
===Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex===




==Overview==
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The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability. pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent. The 1.85 angstrom structure of a 20-residue HIF-1alpha peptide-pVHL-ElonginB-ElonginC complex shows that HIF-1alpha binds to pVHL in an extended beta strand-like conformation. The hydroxyproline inserts into a gap in the pVHL hydrophobic core, at a site that is a hotspot for tumorigenic mutations, with its 4-hydroxyl group recognized by buried serine and histidine residues. Although the beta sheet-like interactions contribute to the stability of the complex, the hydroxyproline contacts are central to the strict specificity characteristic of signaling.
The line below this paragraph, {{ABSTRACT_PUBMED_12004076}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12004076}}


==About this Structure==
==About this Structure==
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[[Category: Regulation]]
[[Category: Regulation]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:03:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:25:00 2008''

Revision as of 18:25, 2 July 2008

File:1lm8.png

Template:STRUCTURE 1lm8

Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex

Template:ABSTRACT PUBMED 12004076

About this Structure

1LM8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling., Min JH, Yang H, Ivan M, Gertler F, Kaelin WG Jr, Pavletich NP, Science. 2002 Jun 7;296(5574):1886-9. Epub 2002 May 9. PMID:12004076

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