1lpe: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1lpe.jpg|left|200px]]
{{Seed}}
[[Image:1lpe.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lpe|  PDB=1lpe  |  SCENE=  }}  
{{STRUCTURE_1lpe|  PDB=1lpe  |  SCENE=  }}  


'''THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E'''
===THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E===




==Overview==
<!--
Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.
The line below this paragraph, {{ABSTRACT_PUBMED_2063194}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 2063194 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_2063194}}


==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Wilson, C.]]
[[Category: Wilson, C.]]
[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:08:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:42:49 2008''

Revision as of 18:42, 2 July 2008

File:1lpe.png

Template:STRUCTURE 1lpe

THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E

Template:ABSTRACT PUBMED 2063194

About this Structure

1LPE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E., Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA, Science. 1991 Jun 28;252(5014):1817-22. PMID:2063194

Page seeded by OCA on Wed Jul 2 21:42:49 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1lpe&oldid=626779"