1lr1: Difference between revisions

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[[Image:1lr1.gif|left|200px]]
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[[Image:1lr1.png|left|200px]]


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{{STRUCTURE_1lr1|  PDB=1lr1  |  SCENE=  }}  
{{STRUCTURE_1lr1|  PDB=1lr1  |  SCENE=  }}  


'''Solution Structure of the Oligomerization Domain of the Bacterial Chromatin-Structuring Protein H-NS'''
===Solution Structure of the Oligomerization Domain of the Bacterial Chromatin-Structuring Protein H-NS===




==Overview==
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H-NS plays a role in condensing DNA in the bacterial nucleoid. This 136 amino acid protein comprises two functional domains separated by a flexible linker. High order structures formed by the N-terminal oligomerization domain (residues 1-89) constitute the basis of a protein scaffold that binds DNA via the C-terminal domain. Deletion of residues 57-89 or 64-89 of the oligomerization domain precludes high order structure formation, yielding a discrete dimer. This dimerization event represents the initial event in the formation of high order structure. The dimers thus constitute the basic building block of the protein scaffold. The three-dimensional solution structure of one of these units (residues 1-57) has been determined. Activity of these structural units is demonstrated by a dominant negative effect on high order structure formation on addition to the full length protein. Truncated and site-directed mutant forms of the N-terminal domain of H-NS reveal how the dimeric unit self-associates in a head-to-tail manner and demonstrate the importance of secondary structure in this interaction to form high order structures. A model is presented for the structural basis for DNA packaging in bacterial cells.
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{{ABSTRACT_PUBMED_12460581}}


==About this Structure==
==About this Structure==
1LR1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR1 OCA].  
1LR1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR1 OCA].  


==Reference==
==Reference==
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[[Category: Dna packaging]]
[[Category: Dna packaging]]
[[Category: Nucleoid assembly]]
[[Category: Nucleoid assembly]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:12:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:50:24 2008''

Revision as of 18:50, 2 July 2008

File:1lr1.png

Template:STRUCTURE 1lr1

Solution Structure of the Oligomerization Domain of the Bacterial Chromatin-Structuring Protein H-NS

Template:ABSTRACT PUBMED 12460581

About this Structure

1LR1 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein., Esposito D, Petrovic A, Harris R, Ono S, Eccleston JF, Mbabaali A, Haq I, Higgins CF, Hinton JC, Driscoll PC, Ladbury JE, J Mol Biol. 2002 Dec 6;324(4):841-50. PMID:12460581

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