1lsp: Difference between revisions

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[[Image:1lsp.jpg|left|200px]]
{{Seed}}
[[Image:1lsp.png|left|200px]]


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{{STRUCTURE_1lsp|  PDB=1lsp  |  SCENE=  }}  
{{STRUCTURE_1lsp|  PDB=1lsp  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF A BULGECIN-INHIBITED G-TYPE LYSOZYME FROM THE EGG-WHITE OF THE AUSTRALIAN BLACK SWAN. A COMPARISON OF THE BINDING OF BULGECIN TO THREE MURAMIDASES'''
===THE CRYSTAL STRUCTURE OF A BULGECIN-INHIBITED G-TYPE LYSOZYME FROM THE EGG-WHITE OF THE AUSTRALIAN BLACK SWAN. A COMPARISON OF THE BINDING OF BULGECIN TO THREE MURAMIDASES===




==Overview==
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Bulgecin A, a bacterial metabolite, has been shown to bind in the active-site groove of the chicken-type lysozyme from the rainbow trout (RBTL) and in the lysozyme-like C-terminal domain, of a soluble lytic transglycosylase (C-SLT) from Escherichia coli. These enzymes are muramidases that cleave the glycosidic bonds in the glycan strands of the murein polymer. Here we report the crystal structure of a complex between the goose-type lysozyme from the egg white of the Australian black swan (SEWL) and bulgecin A at 2.45 A resolution. As is the case for the C-SLT/bulgecin and RBTL/bulgecin complexes, the ligand binds with the N-acetylglucosamine ring in subsite C and the proline moiety in site D where it interacts with the catalytic glutamic acid. The taurine residue interacts with the beta-sheet region. Comparisons of the three buigecin complexes show that the inhibitor has the same binding mode to the muramidases with similar protein-ligand interactions, particularly for SEWL and RBTL. From our results, it seems likely that bulgecin, in general, inhibits enzymes with lysozyme-like domains and thus might represent a novel class of natural antibiotics that act on murein-degrading rather than murein-synthesizing enzymes.
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{{ABSTRACT_PUBMED_15299731}}


==About this Structure==
==About this Structure==
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[[Category: Karlsen, S.]]
[[Category: Karlsen, S.]]
[[Category: Rao, Z H.]]
[[Category: Rao, Z H.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:15:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:04:18 2008''

Revision as of 19:04, 2 July 2008

File:1lsp.png

Template:STRUCTURE 1lsp

THE CRYSTAL STRUCTURE OF A BULGECIN-INHIBITED G-TYPE LYSOZYME FROM THE EGG-WHITE OF THE AUSTRALIAN BLACK SWAN. A COMPARISON OF THE BINDING OF BULGECIN TO THREE MURAMIDASES

Template:ABSTRACT PUBMED 15299731

About this Structure

1LSP is a Single protein structure of sequence from Cygnus atratus. Full crystallographic information is available from OCA.

Reference

Structure of a bulgecin-inhibited g-type lysozyme from the egg white of the Australian black swan. A comparison of the binding of bulgecin to three muramidases., Karlsen S, Hough E, Rao ZH, Isaacs NW, Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):105-14. PMID:15299731

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