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</table>

== Disease ==

[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] ~~Stargardt disease;~~Progressive cone dystrophy;Achromatopsia. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] Progressive cone dystrophy;Stargardt disease;Achromatopsia. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] ~~Visual signal transduction is mediated by a G~~-~~protein coupled cascade using~~ cGMP ~~as second messenger~~. ~~This protein can be activated by~~ cGMP ~~which leads to an opening of~~ the ~~cation~~ channel and ~~thereby causing a~~ depolarization ~~of rod photoreceptors~~. ~~Induced a flickering~~ channel ~~gating, weakened the outward rectification in~~ the presence of ~~extracellular calcium~~, ~~increased sensitivity for L-cis diltiazem and enhanced~~ the ~~cAMP efficiency~~ of the ~~channel when coexpressed with CNGA3 (By similarity)~~. ~~Essential for the generation of light~~-~~evoked electrical responses in the red~~-, ~~green-~~ and ~~blue sensitive cones~~.<ref>PMID:10888875</ref>

[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations.<ref>PMID:10888875</ref> <ref>PMID:12815043</ref> <ref>PMID:34969976</ref> <ref>PMID:37463923</ref>

== Publication Abstract from PubMed ==

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 </table>
 == Disease ==
-[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] Stargardt disease;Progressive cone dystrophy;Achromatopsia. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] Progressive cone dystrophy;Stargardt disease;Achromatopsia. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
 == Function ==
-[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.<ref>PMID:10888875</ref>
+[https://www.uniprot.org/uniprot/CNGB3_HUMAN CNGB3_HUMAN] Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations.<ref>PMID:10888875</ref> <ref>PMID:12815043</ref> <ref>PMID:34969976</ref> <ref>PMID:37463923</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==