1lvq: Difference between revisions

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[[Image:1lvq.gif|left|200px]]
{{Seed}}
[[Image:1lvq.png|left|200px]]


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{{STRUCTURE_1lvq|  PDB=1lvq  |  SCENE=  }}  
{{STRUCTURE_1lvq|  PDB=1lvq  |  SCENE=  }}  


'''IC3 of CB1 Bound to G(alpha)i'''
===IC3 of CB1 Bound to G(alpha)i===




==Overview==
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The structure of the C-terminal region of the third cytoplasmic loop (IC3) of the cannabinoid receptor one (CB1) bound to G(alphai1) has been determined using transferred nuclear Overhauser effects (NOEs). The wild-type IC3 sequence is helical when associated with G(alphai1). In contrast, a peptide containing the amino-acid inversion, Ala(341)-Leu(342) adopts a single turn. These findings correlate with the attenuated G(i) association of CB1 with the Ala(341)-Leu(342) mutation previously observed in vivo and the diminished stimulation of G(alphai1) GTPase activity by the corresponding peptide demonstrated in vitro here. These results, the first to report the structure of a GPCR domain while associated with G protein, imply the C-terminus of CB1 IC3, a region with high-sequence conservation among G-protein coupled receptors, must be helical for efficient coupling and activation of the G(i) protein.
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{{ABSTRACT_PUBMED_12237474}}


==About this Structure==
==About this Structure==
1LVQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVQ OCA].  
1LVQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVQ OCA].  


==Reference==
==Reference==
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[[Category: Helix while bound]]
[[Category: Helix while bound]]
[[Category: Transferred no]]
[[Category: Transferred no]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:31:10 2008''

Revision as of 19:31, 2 July 2008

File:1lvq.png

Template:STRUCTURE 1lvq

IC3 of CB1 Bound to G(alpha)i

Template:ABSTRACT PUBMED 12237474

About this Structure

1LVQ is a Single protein structure. Full experimental information is available from OCA.

Reference

Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity., Ulfers AL, McMurry JL, Miller A, Wang L, Kendall DA, Mierke DF, Protein Sci. 2002 Oct;11(10):2526-31. PMID:12237474

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