1lx5: Difference between revisions

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[[Image:1lx5.~~gif~~|left|200px]]

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~~'''~~Crystal Structure of the BMP7/ActRII Extracellular Domain Complex~~'''~~

===Crystal Structure of the BMP7/ActRII Extracellular Domain Complex===

~~==Overview==~~

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Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related type I and type II receptors. Here we report the crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor. Our structure produces a compelling four-receptor model, ~~revealing that the types I and II receptor ECDs make no direct contacts. Nevertheless~~, ~~we find that truncated receptors lacking their cytoplasmic domain retain~~ the ~~ability~~ to ~~cooperatively assemble in~~ the ~~cell membrane~~. ~~Also~~, the ~~affinity of BMP7 for its low-affinity type I receptor ECD increases 5-fold in the presence of its type II receptor ECD~~. ~~Taken together, our results provide a view of the ligand~~-~~mediated cooperative assembly of BMP and activin receptors that does not rely on receptor~~-~~receptor contacts.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12667445}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12667445 is the PubMed ID number.

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==About this Structure==

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[[Category: Kwiatkowski, W.]]

[[Category: Ligand-receptor complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ ~~3 00~~:23:10 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:44:30 2008''

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-[[Image:1lx5.gif|left|200px]]
+{{Seed}}
+[[Image:1lx5.png|left|200px]]
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 {{STRUCTURE_1lx5|  PDB=1lx5  |  SCENE=  }}
-'''Crystal Structure of the BMP7/ActRII Extracellular Domain Complex'''
+===Crystal Structure of the BMP7/ActRII Extracellular Domain Complex===
-==Overview==
+<!--
-Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related type I and type II receptors. Here we report the crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor. Our structure produces a compelling four-receptor model, revealing that the types I and II receptor ECDs make no direct contacts. Nevertheless, we find that truncated receptors lacking their cytoplasmic domain retain the ability to cooperatively assemble in the cell membrane. Also, the affinity of BMP7 for its low-affinity type I receptor ECD increases 5-fold in the presence of its type II receptor ECD. Taken together, our results provide a view of the ligand-mediated cooperative assembly of BMP and activin receptors that does not rely on receptor-receptor contacts.
+The line below this paragraph, {{ABSTRACT_PUBMED_12667445}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12667445 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12667445}}
 ==About this Structure==
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 [[Category: Kwiatkowski, W.]]
 [[Category: Ligand-receptor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:23:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 22:44:30 2008''