1lxa: Difference between revisions

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[[Image:1lxa.jpg|left|200px]]
{{Seed}}
[[Image:1lxa.png|left|200px]]


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{{STRUCTURE_1lxa|  PDB=1lxa  |  SCENE=  }}  
{{STRUCTURE_1lxa|  PDB=1lxa  |  SCENE=  }}  


'''UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE'''
===UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE===




==Overview==
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UDP-N-acetylglucosamine 3-O-acyltransferase (LpxA) catalyzes the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-N-acetylglucosamine. LpxA is the first enzyme in the lipid A biosynthetic pathway and is a target for the design of antibiotics. The x-ray crystal structure of LpxA has been determined to 2.6 angstrom resolution and reveals a domain motif composed of parallel beta strands, termed a left-handed parallel beta helix (L beta H). This unusual fold displays repeated violations of the protein folding constraint requiring right-handed crossover connections between strands of parallel beta sheets and may be present in other enzymes that share amino acid sequence homology to the repeated hexapeptide motif of LpxA.
The line below this paragraph, {{ABSTRACT_PUBMED_7481807}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7481807 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7481807}}


==About this Structure==
==About this Structure==
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[[Category: Lipid synthesis]]
[[Category: Lipid synthesis]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:45:13 2008''

Revision as of 19:45, 2 July 2008

File:1lxa.png

Template:STRUCTURE 1lxa

UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE

Template:ABSTRACT PUBMED 7481807

About this Structure

1LXA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase., Raetz CR, Roderick SL, Science. 1995 Nov 10;270(5238):997-1000. PMID:7481807

Page seeded by OCA on Wed Jul 2 22:45:13 2008

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