1lyp: Difference between revisions

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[[Image:1lyp.jpg|left|200px]]
{{Seed}}
[[Image:1lyp.png|left|200px]]


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{{STRUCTURE_1lyp|  PDB=1lyp  |  SCENE=  }}  
{{STRUCTURE_1lyp|  PDB=1lyp  |  SCENE=  }}  


'''THE SOLUTION STRUCTURE OF THE ACTIVE DOMAIN OF CAP18: A LIPOPOLYSACCHARIDE BINDING PROTEIN FROM RABBIT LEUKOCYTES'''
===THE SOLUTION STRUCTURE OF THE ACTIVE DOMAIN OF CAP18: A LIPOPOLYSACCHARIDE BINDING PROTEIN FROM RABBIT LEUKOCYTES===




==Overview==
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We have employed the circular dichroism (CD) technique to characterize the solution structure of CAP18(106-137), a lipopolysaccharide (LPS) binding, antimicrobial protein, and its interaction with lipid A. Our results revealed that CAP18(106-137) may exist in at least three lipid A concentration-dependent, primarily helix conformations. The 'model' structure of CAP18(106-137) in 30% (v/v) TFE, determined by nuclear magnetic resonance (NMR) technique, was found to be a complete and very rigid helix. In this conformation, the cationic and hydrophobic groups of CAP18(106-137) are separated into patches and stripes in such a way that it can favorably interact with lipid A through either coulombic interaction with the diphosphoryl groups or hydrophobic interaction with the fatty acyl chains.
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(as it appears on PubMed at http://www.pubmed.gov), where 7649303 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7649303}}


==About this Structure==
==About this Structure==
1LYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LYP OCA].  
1LYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LYP OCA].  


==Reference==
==Reference==
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[[Category: Huang, T H.]]
[[Category: Huang, T H.]]
[[Category: Lipopolysaccharide-binding protein]]
[[Category: Lipopolysaccharide-binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:25:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:50:07 2008''
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