8jyz: Difference between revisions
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==Cryo-EM structure of RCD-1 pore from Neurospora crassa== | |||
<StructureSection load='8jyz' size='340' side='right'caption='[[8jyz]], [[Resolution|resolution]] 3.63Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8jyz]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JYZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.63Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jyz OCA], [https://pdbe.org/8jyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jyz RCSB], [https://www.ebi.ac.uk/pdbsum/8jyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jyz ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RCD11_NEUCR RCD11_NEUCR] Gasdermin-like protein involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition) (PubMed:31636083, PubMed:32703806). In N.crassa, the rcd-1 locus exists as 2 incompatible alleles, rcd-1-1 (this entry) and rcd-1-2 (AC P0DW10) (PubMed:31636083). During the allorecognition process, forms a heterooligomer with rcd-1-2, thereby forming a functional gasdermin-like complex that binds to membranes and forms pores, triggering cell death (PubMed:32703806). Binds negatively charged phospholipids, such as cardiolipin and phosphatidylserine (PubMed:32703806). Also binds to phosphoinositides, preferentially to phosphatidylinositol-3-phosphate (PtdIns-3-P), PtdIns-5-P and PtdIns-3,5-P2 (PubMed:32703806).<ref>PMID:31636083</ref> <ref>PMID:32703806</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Neurospora crassa]] | |||
[[Category: Ding J]] | |||
[[Category: Hou YJ]] | |||
[[Category: Li Y]] | |||
[[Category: Sun Q]] | |||
Revision as of 06:20, 1 May 2024
Cryo-EM structure of RCD-1 pore from Neurospora crassa
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