8jzm: Difference between revisions
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The | ==The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210== | ||
<StructureSection load='8jzm' size='340' side='right'caption='[[8jzm]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8jzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JZM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jzm OCA], [https://pdbe.org/8jzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jzm RCSB], [https://www.ebi.ac.uk/pdbsum/8jzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jzm ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Jia | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> | ||
[[Category: Mobli | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Jia X]] | |||
[[Category: Kobe B]] | |||
[[Category: Maxwell MJ]] | |||
[[Category: Mobli M]] | |||
[[Category: Rahaman MH]] | |||
Latest revision as of 06:20, 1 May 2024
The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210
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