8tlo: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 8tlo is ON HOLD  until Paper Publication
==Crystal Structure Analysis of BCL11A in complex with DNA==
 
<StructureSection load='8tlo' size='340' side='right'caption='[[8tlo]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
Authors: Seo, H.-S., Dhe-Paganon, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8tlo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TLO FirstGlance]. <br>
Description: Crystal Structure Analysis of BCL11A in complex with DNA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.76&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tlo OCA], [https://pdbe.org/8tlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tlo RCSB], [https://www.ebi.ac.uk/pdbsum/8tlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tlo ProSAT]</span></td></tr>
[[Category: Dhe-Paganon, S]]
</table>
[[Category: Seo, H.-S]]
== Disease ==
[https://www.uniprot.org/uniprot/BC11A_HUMAN BC11A_HUMAN] Hereditary persistence of fetal hemoglobin - beta-thalassemia. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification.<ref>PMID:11719382</ref>  The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:27453576</ref>
== Function ==
[https://www.uniprot.org/uniprot/BC11A_HUMAN BC11A_HUMAN] Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).[UniProtKB:Q9QYE3]<ref>PMID:26375765</ref> <ref>PMID:27453576</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dhe-Paganon S]]
[[Category: Seo H-S]]
Retrieved from "https://proteopedia.org/8tlo"