1m1f: Difference between revisions

Line 1:

[[Image:1m1f.~~jpg~~|left|200px]]

[[Image:1m1f.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Kid toxin protein from E.coli plasmid R1~~'''~~

===Kid toxin protein from E.coli plasmid R1===

~~==Overview==~~

<!--

~~We have determined the structure of Kid toxin protein from E. coli plasmid R1 involved in stable plasmid inheritance by postsegregational killing of plasmid~~-~~less daughter cells. Kid forms a two~~-~~component system with its antagonist~~, ~~Kis antitoxin. Our 1.4 A crystal structure of Kid reveals a 2-fold symmetric dimer that closely resembles~~ the ~~DNA gyrase-inhibitory toxin protein CcdB from E. coli F plasmid despite~~ the ~~lack of any notable sequence similarity~~. ~~Analysis of nontoxic mutants of Kid suggests a target interaction interface associated with toxicity that is in marked contrast to that proposed for CcdB~~. ~~A possible region for interaction of Kid with the antitoxin~~ is ~~proposed that overlaps with~~ the ~~target binding site and may explain the mode of antitoxin action~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12377128}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12377128 is the PubMed ID number.

-->

==About this Structure==

Line 36:

Line 40:

[[Category: Post segregational killing]]

[[Category: Toxin-antitoxin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ 3 00:~~31:01~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:00:41 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1m1f.jpg|left|200px]]
+{{Seed}}
+[[Image:1m1f.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1m1f|  PDB=1m1f  |  SCENE=  }}
-'''Kid toxin protein from E.coli plasmid R1'''
+===Kid toxin protein from E.coli plasmid R1===
-==Overview==
+<!--
-We have determined the structure of Kid toxin protein from E. coli plasmid R1 involved in stable plasmid inheritance by postsegregational killing of plasmid-less daughter cells. Kid forms a two-component system with its antagonist, Kis antitoxin. Our 1.4 A crystal structure of Kid reveals a 2-fold symmetric dimer that closely resembles the DNA gyrase-inhibitory toxin protein CcdB from E. coli F plasmid despite the lack of any notable sequence similarity. Analysis of nontoxic mutants of Kid suggests a target interaction interface associated with toxicity that is in marked contrast to that proposed for CcdB. A possible region for interaction of Kid with the antitoxin is proposed that overlaps with the target binding site and may explain the mode of antitoxin action.
+The line below this paragraph, {{ABSTRACT_PUBMED_12377128}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12377128 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12377128}}
 ==About this Structure==
@@ Line 36: / Line 40: @@
 [[Category: Post segregational killing]]
 [[Category: Toxin-antitoxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:31:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:00:41 2008''