1m11: Difference between revisions

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[[Image:1m11.gif|left|200px]]<br />

[[Image:1m11.gif|left|200px]]<br /><applet load="1m11" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1m11" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1m11, resolution 16.0Å" />

'''structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy'''<br />

==Overview==

Echoviruses are enteroviruses that belong to Picornaviridae. Many, echoviruses use decay-accelerating factor (DAF) as their cellular, receptor. DAF is a glycosylphosphatidyl inositol-anchored complement, regulatory protein found on most cell surfaces. It functions to protect, cells from complement attack. The cryo-electron microscopy reconstructions, of echovirus 7 complexed with DAF show that the DAF-binding regions are, located close to the icosahedral twofold axes, in contrast to other, enterovirus complexes where the viral canyon is the receptor binding site., This novel receptor binding position suggests that DAF is important for, the attachment of viral particles to host cells, but probably not for, initiating viral uncoating, as is the case with canyon-binding receptors., Thus, a different cell entry mechanism must be used for enteroviruses that, bind DAF.

Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding regions are located close to the icosahedral twofold axes, in contrast to other enterovirus complexes where the viral canyon is the receptor binding site. This novel receptor binding position suggests that DAF is important for the attachment of viral particles to host cells, but probably not for initiating viral uncoating, as is the case with canyon-binding receptors. Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF.

==Disease==

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==About this Structure==

1M11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA].

1M11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA].

==Reference==

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[[Category: Human echovirus 6]]

[[Category: Protein complex]]

[[Category: Baker, T.S.]]

[[Category: Baker, T S.]]

[[Category: Bator, C.M.]]

[[Category: Bator, C M.]]

[[Category: Chipman, P.R.]]

[[Category: Chipman, P R.]]

[[Category: He, Y.]]

[[Category: Kuhn, R.J.]]

[[Category: Kuhn, R J.]]

[[Category: Lin, F.]]

[[Category: Medof, M.E.]]

[[Category: Medof, M E.]]

[[Category: Rossmann, M.G.]]

[[Category: Rossmann, M G.]]

[[Category: Shoham, M.]]

[[Category: decay-accelerating factor]]

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[[Category: scr]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 18~~:05:~~50 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:50:20 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1m11.gif|left|200px]]<br />
+[[Image:1m11.gif|left|200px]]<br /><applet load="1m11" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1m11" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1m11, resolution 16.0&Aring;" />
 '''structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy'''<br />
 ==Overview==
-Echoviruses are enteroviruses that belong to Picornaviridae. Many, echoviruses use decay-accelerating factor (DAF) as their cellular, receptor. DAF is a glycosylphosphatidyl inositol-anchored complement, regulatory protein found on most cell surfaces. It functions to protect, cells from complement attack. The cryo-electron microscopy reconstructions, of echovirus 7 complexed with DAF show that the DAF-binding regions are, located close to the icosahedral twofold axes, in contrast to other, enterovirus complexes where the viral canyon is the receptor binding site., This novel receptor binding position suggests that DAF is important for, the attachment of viral particles to host cells, but probably not for, initiating viral uncoating, as is the case with canyon-binding receptors., Thus, a different cell entry mechanism must be used for enteroviruses that, bind DAF.
+Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding regions are located close to the icosahedral twofold axes, in contrast to other enterovirus complexes where the viral canyon is the receptor binding site. This novel receptor binding position suggests that DAF is important for the attachment of viral particles to host cells, but probably not for initiating viral uncoating, as is the case with canyon-binding receptors. Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-M11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA].
+M11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Human echovirus 6]]
 [[Category: Protein complex]]
-[[Category: Baker, T.S.]]
+[[Category: Baker, T S.]]
-[[Category: Bator, C.M.]]
+[[Category: Bator, C M.]]
-[[Category: Chipman, P.R.]]
+[[Category: Chipman, P R.]]
 [[Category: He, Y.]]
-[[Category: Kuhn, R.J.]]
+[[Category: Kuhn, R J.]]
 [[Category: Lin, F.]]
-[[Category: Medof, M.E.]]
+[[Category: Medof, M E.]]
-[[Category: Rossmann, M.G.]]
+[[Category: Rossmann, M G.]]
 [[Category: Shoham, M.]]
 [[Category: decay-accelerating factor]]
@@ Line 31: / Line 30: @@
 [[Category: scr]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:05:50 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:50:20 2008''