1m4v: Difference between revisions

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[[Image:1m4v.gif|left|200px]]
{{Seed}}
[[Image:1m4v.png|left|200px]]


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{{STRUCTURE_1m4v|  PDB=1m4v  |  SCENE=  }}  
{{STRUCTURE_1m4v|  PDB=1m4v  |  SCENE=  }}  


'''Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus'''
===Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus===




==Overview==
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The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.
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{{ABSTRACT_PUBMED_12082105}}


==About this Structure==
==About this Structure==
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[[Category: Ob-fold]]
[[Category: Ob-fold]]
[[Category: Superantigen fold]]
[[Category: Superantigen fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:37:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:12:48 2008''

Revision as of 20:12, 2 July 2008

File:1m4v.png

Template:STRUCTURE 1m4v

Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus

Template:ABSTRACT PUBMED 12082105

About this Structure

1M4V is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome., Arcus VL, Langley R, Proft T, Fraser JD, Baker EN, J Biol Chem. 2002 Aug 30;277(35):32274-81. Epub 2002 Jun 24. PMID:12082105

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