1m51: Difference between revisions

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[[Image:1m51.gif|left|200px]]
{{Seed}}
[[Image:1m51.png|left|200px]]


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{{STRUCTURE_1m51|  PDB=1m51  |  SCENE=  }}  
{{STRUCTURE_1m51|  PDB=1m51  |  SCENE=  }}  


'''PEPCK complex with a GTP-competitive inhibitor'''
===PEPCK complex with a GTP-competitive inhibitor===




==Overview==
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The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented.
The line below this paragraph, {{ABSTRACT_PUBMED_14552798}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14552798 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14552798}}


==Disease==
==Disease==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Xanthine]]
[[Category: Xanthine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:13:34 2008''