8k8d: Difference between revisions

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'''Unreleased structure'''


The entry 8k8d is ON HOLD  until Paper Publication
==Crystal structure of C/EBPbeta BZIP domain bound to a high affinity DNA==
 
<StructureSection load='8k8d' size='340' side='right'caption='[[8k8d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Min, J.R., Chen, S.Z., Liu, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8k8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K8D FirstGlance]. <br>
Description: Crystal structure of C/EBPbeta BZIP domain bound to a high affinity DNA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k8d OCA], [https://pdbe.org/8k8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k8d RCSB], [https://www.ebi.ac.uk/pdbsum/8k8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k8d ProSAT]</span></td></tr>
[[Category: Min, J.R]]
</table>
[[Category: Liu, K]]
== Function ==
[[Category: Chen, S.Z]]
[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Chen SZ]]
[[Category: Liu K]]
[[Category: Min JR]]
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