8kb4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8kb4 is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of human TMEM87A A308M==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8kb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KB4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8KB4 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=65I:(9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl+undecanoate'>65I</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8kb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kb4 OCA], [https://pdbe.org/8kb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8kb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kb4 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TM87A_HUMAN TM87A_HUMAN] May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (PubMed:26157166). In one study, shown to be a component of a novel mechanoelectrical transduction pathway which is involved in cell adhesion and migration, and is thought to act either as a mechanically activated ion channel or as an accessory protein which modulates an unidentified mechanically activated ion channel (PubMed:32228863). In another study, neither basal nor mechanically activated channel activity has been observed and, based on structural similarity with WLS, has been suggested to function as a trafficking chaperone for membrane-associated cargo (PubMed:36373655).<ref>PMID:26157166</ref> <ref>PMID:32228863</ref> <ref>PMID:36373655</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Human adenovirus 2]]

[[Category: Large Structures]]

[[Category: Han A]]

[[Category: Kim HM]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8kb4 is ON HOLD  until Paper Publication
+==Cryo-EM structure of human TMEM87A A308M==
+<StructureSection load='8kb4' size='340' side='right'caption='[[8kb4]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8kb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KB4 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=65I:(9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl+undecanoate'>65I</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kb4 OCA], [https://pdbe.org/8kb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8kb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kb4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TM87A_HUMAN TM87A_HUMAN] May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (PubMed:26157166). In one study, shown to be a component of a novel mechanoelectrical transduction pathway which is involved in cell adhesion and migration, and is thought to act either as a mechanically activated ion channel or as an accessory protein which modulates an unidentified mechanically activated ion channel (PubMed:32228863). In another study, neither basal nor mechanically activated channel activity has been observed and, based on structural similarity with WLS, has been suggested to function as a trafficking chaperone for membrane-associated cargo (PubMed:36373655).<ref>PMID:26157166</ref> <ref>PMID:32228863</ref> <ref>PMID:36373655</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Human adenovirus 2]]
+[[Category: Large Structures]]
+[[Category: Han A]]
+[[Category: Kim HM]]