8i5e: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i5e OCA], [https://pdbe.org/8i5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i5e RCSB], [https://www.ebi.ac.uk/pdbsum/8i5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i5e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i5e OCA], [https://pdbe.org/8i5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i5e RCSB], [https://www.ebi.ac.uk/pdbsum/8i5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i5e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
[https://www.uniprot.org/uniprot/U5YJJ6_HUMAN U5YJJ6_HUMAN]  
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 07:22, 21 November 2024

Crystal structure of HLA-A*11:01 in complex with KRAS peptide (VVGAGGVGK)

8i5e, resolution 2.20Å

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