1m6d: Difference between revisions

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[[Image:1m6d.gif|left|200px]]
{{Seed}}
[[Image:1m6d.png|left|200px]]


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{{STRUCTURE_1m6d|  PDB=1m6d  |  SCENE=  }}  
{{STRUCTURE_1m6d|  PDB=1m6d  |  SCENE=  }}  


'''Crystal structure of human cathepsin F'''
===Crystal structure of human cathepsin F===




==Overview==
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Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with the major histocompatibility complex (MHC) class II. Evidence suggests that inhibiting cathepsin F activity will block MHC class II processing in macrophages. Consequently, inhibitors of this enzyme may be useful in treating certain diseases that involve an inappropriate or excessive immune response. We have determined the 1.7A structure of the mature domain of human cathepsin F associated with an irreversible vinyl sulfone inhibitor. This structure provides a basis for understanding cathepsin F's substrate specificity, and suggests ways of identifying potent and selective inhibitors of this enzyme.
The line below this paragraph, {{ABSTRACT_PUBMED_12225749}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12225749 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12225749}}


==About this Structure==
==About this Structure==
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[[Category: Somoza, J R.]]
[[Category: Somoza, J R.]]
[[Category: Papain family cysteine protease]]
[[Category: Papain family cysteine protease]]
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