1m6o: Difference between revisions
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'''Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide'''<br /> | '''Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1M6O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1M6O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6O OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: signal]] | [[Category: signal]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:22:17 2008'' | ||
Revision as of 14:22, 15 February 2008
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Crystal Structure of HLA B*4402 in complex with HLA DPA*0201 peptide
Overview
HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are, both found at a high frequency in all human populations, and yet they only, differ by one residue on the alpha2 helix (B*4402 Asp156-->B*4403 Leu156)., CTLs discriminate between HLA-B*4402 and B*4403, and these allotypes, stimulate strong mutual allogeneic responses reflecting their known, barrier to hemopoeitic stem cell transplantation. Although HLA-B*4402 and, B*4403 share >95% of their peptide repertoire, B*4403 presents more unique, peptides than B*4402, consistent with the stronger T cell alloreactivity, observed toward B*4403 compared with B*4402. Crystal structures of B*4402, and B*4403 show how the polymorphism at position 156 is completely buried, and yet alters both the peptide and the heavy chain conformation, relaxing, ligand selection by B*4403 compared with B*4402. Thus, the polymorphism, between HLA-B*4402 and B*4403 modifies both peptide repertoire and T cell, recognition, and is reflected in the paradoxically powerful alloreactivity, that occurs across this "minimal" mismatch. The findings suggest that, these closely related class I genes are maintained in diverse human, populations through their differential impact on the selection of peptide, ligands and the T cell repertoire.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142830], Hypoproteinemia, hypercatabolic OMIM:[109700], Spondyloarthropathy, susceptibility to, 1 OMIM:[142830], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[142830]
About this Structure
1M6O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition., Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J, J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25. PMID:12939341
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