1m82: Difference between revisions

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[[Image:1m82.gif|left|200px]]
{{Seed}}
[[Image:1m82.png|left|200px]]


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{{STRUCTURE_1m82|  PDB=1m82  |  SCENE=  }}  
{{STRUCTURE_1m82|  PDB=1m82  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE COMPLEMENTARY RNA PROMOTER OF INFLUENZA A VIRUS'''
===SOLUTION STRUCTURE OF THE COMPLEMENTARY RNA PROMOTER OF INFLUENZA A VIRUS===




==Overview==
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Influenza A virus replication requires the interaction of viral RNA-dependent RNA polymerase (RdRp) with promoters in both the RNA genome (vRNA) and the full-length complementary RNA (cRNA) which serve as templates for the generation of new vRNAs. Although RdRp binds both promoters effectively, it must also discriminate between them because they serve different functional roles in the viral life cycle. Even though the inherent asymmetry between two RNA promoters is considered as a cause of the differential recognition by the RdRp, the structural basis for the ability of the RdRp to recognize the RNA promoters and discriminate effectively between them remains unsolved. Here we report the structure of the cRNA promoter of influenza A virus as determined by heteronuclear magnetic resonance spectroscopy. The terminal region is extremely unstable and does not have a rigid structure. The major groove of the internal loop is widened by the displacement of a novel A*(UU) motif toward the minor groove. These internal loop residues show distinguishable dynamic characters, with differing motional timescales for each residue. Comparison of the cRNA promoter structure with that of the vRNA promoter reveals common structural and dynamic elements in the internal loop, but also differences that provide insight into how the viral RdRp differentially recognizes the cRNA and vRNA promoters.
The line below this paragraph, {{ABSTRACT_PUBMED_12771209}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12771209 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12771209}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M82 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M82 OCA].  


==Reference==
==Reference==
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[[Category: A-form helix]]
[[Category: A-form helix]]
[[Category: Asymmetric internal loop]]
[[Category: Asymmetric internal loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:45:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:24:58 2008''

Revision as of 20:25, 2 July 2008

File:1m82.png

Template:STRUCTURE 1m82

SOLUTION STRUCTURE OF THE COMPLEMENTARY RNA PROMOTER OF INFLUENZA A VIRUS

Template:ABSTRACT PUBMED 12771209

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase., Park CJ, Bae SH, Lee MK, Varani G, Choi BS, Nucleic Acids Res. 2003 Jun 1;31(11):2824-32. PMID:12771209

Page seeded by OCA on Wed Jul 2 23:24:58 2008

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