1m9o: Difference between revisions

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[[Image:1m9o.~~gif~~|left|200px]]

[[Image:1m9o.png|left|200px]]

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~~'''~~NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11~~'''~~

===NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11===

~~==Overview==~~

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~~Nup475~~ (~~also known~~ as ~~tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His~~. ~~These domains are required for rapid degradation of tumor necrosis factor (TNF~~) ~~and other mRNAs through~~ the ~~interaction with AU-rich elements in their 3'-untranslated regions~~. ~~The three~~-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.

The line below this paragraph, {{ABSTRACT_PUBMED_12515557}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12515557 is the PubMed ID number.

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==About this Structure==

1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].

1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].

==Reference==

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[[Category: Worthington, M T.]]

[[Category: Cys3his type zinc finger]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ ~~3 00~~:47:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:30:28 2008''

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-[[Image:1m9o.gif|left|200px]]
+{{Seed}}
+[[Image:1m9o.png|left|200px]]
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 {{STRUCTURE_1m9o|  PDB=1m9o  |  SCENE=  }}
-'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''
+===NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11===
-==Overview==
+<!--
-Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_12515557}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12515557 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12515557}}
 ==About this Structure==
-M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].
+M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].
 ==Reference==
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 [[Category: Worthington, M T.]]
 [[Category: Cys3his type zinc finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:47:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:30:28 2008''