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[[Image:1mag.jpg|left|200px]]
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'''GRAMICIDIN A IN HYDRATED DMPC BILAYERS, SOLID STATE NMR'''
===GRAMICIDIN A IN HYDRATED DMPC BILAYERS, SOLID STATE NMR===




==Overview==
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The complete structure determination of a polypeptide in a lipid bilayer environment is demonstrated built solely upon orientational constraints derived from solid-state NMR observations. Such constraints are obtained from isotopically labeled samples uniformly aligned with respect to the B(0) field. Each observation constrains the molecular frame with respect to B(0) and the bilayer normal, which are arranged to be parallel. These constraints are not only very precise ( a few tenths of a degree), but also very accurate. This is clearly demonstrated as the backbone structure is assembled sequentially and the i to i + 6 hydrogen bonds in this structure of the gramicidin channel are shown on average to be within 0.5 A of ideal geometry. Similarly, the side chains are assembled independently and in a radial direction from the backbone. The lack of considerable atomic overlap between side chains also demonstrates the accuracy of the constraints. Through this complete structure, solid-state NMR is demonstrated as an approach for determining three-dimensional macromolecular structure.
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==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MAG OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MAG OCA].  


==Reference==
==Reference==
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[[Category: Peptide antibiotic]]
[[Category: Peptide antibiotic]]
[[Category: Side chain conformation]]
[[Category: Side chain conformation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:49:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:33:33 2008''

Revision as of 20:33, 2 July 2008

File:1mag.png

Template:STRUCTURE 1mag

GRAMICIDIN A IN HYDRATED DMPC BILAYERS, SOLID STATE NMR

Template:ABSTRACT PUBMED 8810522

About this Structure

Full experimental information is available from OCA.

Reference

Macromolecular structural elucidation with solid-state NMR-derived orientational constraints., Ketchem RR, Lee KC, Huo S, Cross TA, J Biomol NMR. 1996 Jul;8(1):1-14. PMID:8810522

Page seeded by OCA on Wed Jul 2 23:33:33 2008

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