1mb8: Difference between revisions

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[[Image:1mb8.gif|left|200px]]
{{Seed}}
[[Image:1mb8.png|left|200px]]


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{{STRUCTURE_1mb8|  PDB=1mb8  |  SCENE=  }}  
{{STRUCTURE_1mb8|  PDB=1mb8  |  SCENE=  }}  


'''Crystal Structure of the actin binding domain of plectin'''
===Crystal Structure of the actin binding domain of plectin===




==Overview==
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Plectin is a widely expressed cytoskeletal linker. Here we report the crystal structure of the actin binding domain of plectin and show that this region is sufficient for interaction with F-actin or the cytoplasmic region of integrin alpha6beta4. The structure is formed by two calponin homology domains arranged in a closed conformation. We show that binding to F-actin induces a conformational change in plectin that is inhibited by an engineered interdomain disulfide bridge. A two-step induced fit mechanism involving binding and subsequent domain rearrangement is proposed. In contrast, interaction with integrin alpha6beta4 occurs in a closed conformation. Competitive binding of plectin to F-actin and integrin alpha6beta4 may rely on the observed alternative binding mechanisms and involve both allosteric and steric factors.
The line below this paragraph, {{ABSTRACT_PUBMED_12791251}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12791251}}


==About this Structure==
==About this Structure==
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[[Category: Epidermolysis bullosa]]
[[Category: Epidermolysis bullosa]]
[[Category: Integrin beta4 hemidesmosome]]
[[Category: Integrin beta4 hemidesmosome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:50:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:36:31 2008''
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