296d: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=296d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=296d OCA], [https://pdbe.org/296d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=296d RCSB], [https://www.ebi.ac.uk/pdbsum/296d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=296d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=296d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=296d OCA], [https://pdbe.org/296d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=296d RCSB], [https://www.ebi.ac.uk/pdbsum/296d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=296d ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bis-benzimidazole drug Hoechst 33258 has been co-crystallized with the dodecanucleotide sequence d(CGCAAATTTGCG)2. The structure has been solved by molecular replacement and refined to an R factor of 18.5% for 2125 reflections collected on a Xentronics area detector. The drug is bound in the minor groove, at the five base-pair site 5'-ATTTG and is in a unique orientation. This is displaced by one base pair in the 5' direction compared to previously-determined structures of this drug with the sequence d(CGCGAATTCGCG)2. Reasons for this difference in behaviour are discussed in terms of several sequence-dependent structural features of the DNA, with particular reference to differences in propeller twist and minor-groove width.
Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex.,Spink N, Brown DG, Skelly JV, Neidle S Nucleic Acids Res. 1994 May 11;22(9):1607-12. PMID:7515488<ref>PMID:7515488</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 296d" style="background-color:#fffaf0;"></div>
== References ==
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