8ke7: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8ke7 is ~~ON HOLD until Paper Publication~~

==Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8ke7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KE7 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8KE7 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8ke7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ke7 OCA], [https://pdbe.org/8ke7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ke7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ke7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ke7 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chan NL]]

[[Category: Chen SF]]

[[Category: Liu KT]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8ke7 is ON HOLD  until Paper Publication
+==Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation==
+<StructureSection load='8ke7' size='340' side='right'caption='[[8ke7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ke7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KE7 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ke7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ke7 OCA], [https://pdbe.org/8ke7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ke7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ke7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ke7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chan NL]]
+[[Category: Chen SF]]
+[[Category: Liu KT]]