1me3: Difference between revisions

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[[Image:1me3.jpg|left|200px]]
{{Seed}}
[[Image:1me3.png|left|200px]]


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{{STRUCTURE_1me3|  PDB=1me3  |  SCENE=  }}  
{{STRUCTURE_1me3|  PDB=1me3  |  SCENE=  }}  


'''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)'''
===High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)===




==Overview==
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The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
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{{ABSTRACT_PUBMED_12467703}}


==About this Structure==
==About this Structure==
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[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
[[Category: Non-covalent inhibitor]]
[[Category: Non-covalent inhibitor]]
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