8e8w: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/SZNF_STRC2 SZNF_STRC2] Involved in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin (SZN) (PubMed:30728519, PubMed:30763082). Catalyzes a complex multi-step reaction: the overall reaction is an oxidative rearrangement of the guanidine group of N(omega)-methyl-L-arginine (L-NMA), generating an N-nitrosourea product (PubMed:30728519, PubMed:30763082, PubMed:32511919). SznF first hydroxylates L-NMA to form N(delta)-hydroxy-N(omega)-methyl-L-arginine (L-HMA), which is further hydroxylated to give N(delta)-hydroxy-N(omega)-hydroxy-N(omega)-methyl-L-arginine (L-DHMA) (PubMed:30728519, PubMed:32511919). Subsequently, an oxidative rearrangement converts this intermediate to N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline (PubMed:30728519, PubMed:34004115). This product is unstable, and degrades non-enzymically into nitric oxide and the denitrosated product N(delta)-hydroxy-N(omega)-methyl-L-citrulline (PubMed:30728519).<ref>PMID:30728519</ref> <ref>PMID:30763082</ref> <ref>PMID:32511919</ref> <ref>PMID:34004115</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
