1mfy: Difference between revisions

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[[Image:1mfy.gif|left|200px]]
{{Seed}}
[[Image:1mfy.png|left|200px]]


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{{STRUCTURE_1mfy|  PDB=1mfy  |  SCENE=  }}  
{{STRUCTURE_1mfy|  PDB=1mfy  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF INFLUENZA A VIRUS C4 PROMOTER'''
===SOLUTION STRUCTURE OF INFLUENZA A VIRUS C4 PROMOTER===




==Overview==
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The influenza A virus promoter is recognized by the influenza A virus RNA-dependent RNA polymerase, and directs both transcription and replication of the viral RNA genome. Within the sequence of this promoter, flu strains exhibit a natural, unique variation, either a U or a C, at the fourth position from the 3' end. Promoters that contain a C residue (C4 promoter), which are invariably found in genome segments that encode the three RNA polymerase subunits (PB1, PB2 and PA), down-regulate transcription but activate genome replication. Here, we have determined the structure of the C4 promoter by NMR spectroscopy and compared it with the structure of the U4 promoter, which was determined previously. The structure of the internal loop in the C4 promoter is similar to that of the U4 promoter. However, the terminal stem of the C4 promoter is strikingly different from that of the U4 promoter. These structural data suggest that the internal loop is important for polymerase binding to the promoter, and the terminal stem is crucial for differential regulation of transcription and replication.
The line below this paragraph, {{ABSTRACT_PUBMED_12582241}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12582241 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12582241}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFY OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFY OCA].  


==Reference==
==Reference==
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[[Category: Natural variant]]
[[Category: Natural variant]]
[[Category: Single adenine bulge]]
[[Category: Single adenine bulge]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:59:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:53:28 2008''

Revision as of 20:53, 2 July 2008

File:1mfy.png

Template:STRUCTURE 1mfy

SOLUTION STRUCTURE OF INFLUENZA A VIRUS C4 PROMOTER

Template:ABSTRACT PUBMED 12582241

About this Structure

Full experimental information is available from OCA.

Reference

A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase., Lee MK, Bae SH, Park CJ, Cheong HK, Cheong C, Choi BS, Nucleic Acids Res. 2003 Feb 15;31(4):1216-23. PMID:12582241

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