1mgp: Difference between revisions

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[[Image:1mgp.gif|left|200px]]
{{Seed}}
[[Image:1mgp.png|left|200px]]


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{{STRUCTURE_1mgp|  PDB=1mgp  |  SCENE=  }}  
{{STRUCTURE_1mgp|  PDB=1mgp  |  SCENE=  }}  


'''Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function'''
===Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function===




==Overview==
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We determined the three-dimensional (3D) crystal structure of protein TM841, a protein product from a hypothetical open-reading frame in the genome of the hyperthermophile bacterium Thermotoga maritima, to 2.0 A resolution. The protein belongs to a large protein family, DegV or COG1307 of unknown function. The 35 kDa protein consists of two separate domains, with low-level structural resemblance to domains from other proteins with known 3D structures. These structural homologies, however, provided no clues for the function of TM841. But the electron density maps revealed clear density for a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that TM841 has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism.
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{{ABSTRACT_PUBMED_12577257}}


==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Two domain structure with mixed alpha/beta structures in both domain]]
[[Category: Two domain structure with mixed alpha/beta structures in both domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:00:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:55:10 2008''

Revision as of 20:55, 2 July 2008

File:1mgp.png

Template:STRUCTURE 1mgp

Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function

Template:ABSTRACT PUBMED 12577257

About this Structure

1MGP is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein., Schulze-Gahmen U, Pelaschier J, Yokota H, Kim R, Kim SH, Proteins. 2003 Mar 1;50(4):526-30. PMID:12577257

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