1mj1: Difference between revisions

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[[Image:1mj1.~~gif~~|left|200px]]

[[Image:1mj1.png|left|200px]]

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~~'''~~FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME~~'''~~

===FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME===

~~==Overview==~~

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The ~~mRNA codon in~~ the ~~ribosomal A-site is recognized by aminoacyl-tRNA~~ (~~aa-tRNA) in a ternary complex with elongation factor Tu (EF-Tu) and GTP~~. ~~Here we report the 13 A resolution three-dimensional reconstruction determined by cryo-electron microscopy of the kirromycin-stalled codon-recognition complex~~. ~~The structure of the ternary complex~~ is ~~distorted by binding of~~ the ~~tRNA anticodon arm in the decoding center~~. ~~The aa-tRNA interacts with 16S rRNA, helix 69 of 23S rRNA and proteins S12 and L11, while the sarcin~~-~~ricin loop of 23S rRNA contacts domain 1 of EF~~-~~Tu near the nucleotide-binding pocket. These results provide a detailed snapshot view of an important functional state of the ribosome and suggest mechanisms of decoding and GTPase activation.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12379845}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12379845 is the PubMed ID number.

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==About this Structure==

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[[Category: Ef-tu]]

[[Category: Low resolution model ternary complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ 3 01:08:52 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:04:59 2008''

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-[[Image:1mj1.gif|left|200px]]
+{{Seed}}
+[[Image:1mj1.png|left|200px]]
 <!--
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 {{STRUCTURE_1mj1|  PDB=1mj1  |  SCENE=  }}
-'''FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME'''
+===FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME===
-==Overview==
+<!--
-The mRNA codon in the ribosomal A-site is recognized by aminoacyl-tRNA (aa-tRNA) in a ternary complex with elongation factor Tu (EF-Tu) and GTP. Here we report the 13 A resolution three-dimensional reconstruction determined by cryo-electron microscopy of the kirromycin-stalled codon-recognition complex. The structure of the ternary complex is distorted by binding of the tRNA anticodon arm in the decoding center. The aa-tRNA interacts with 16S rRNA, helix 69 of 23S rRNA and proteins S12 and L11, while the sarcin-ricin loop of 23S rRNA contacts domain 1 of EF-Tu near the nucleotide-binding pocket. These results provide a detailed snapshot view of an important functional state of the ribosome and suggest mechanisms of decoding and GTPase activation.
+The line below this paragraph, {{ABSTRACT_PUBMED_12379845}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12379845 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12379845}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Ef-tu]]
 [[Category: Low resolution model ternary complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:08:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:04:59 2008''