1mjg: Difference between revisions

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[[Image:1mjg.~~gif~~|left|200px]]

[[Image:1mjg.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)~~'''~~

===CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)===

~~==Overview==~~

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~~A metallocofactor containing iron~~, ~~sulfur~~, ~~copper, and nickel has been discovered in~~ the ~~enzyme carbon monoxide dehydrogenase/acetyl-CoA~~ (~~coenzyme A) synthase from Moorella thermoacetica (f. Clostridium thermoaceticum). Our structure~~ at 2.~~2 angstrom resolution reveals that the cofactor responsible for the assembly of acetyl-CoA contains a [Fe4S4] cubane bridged to a copper-nickel binuclear site~~. The presence of these three metals together in one cluster was unanticipated and suggests a newly discovered role for copper in biology. The different active sites of this bifunctional enzyme complex are connected via a channel, ~~138 angstroms long, that provides a conduit for carbon monoxide generated at~~ the C-~~cluster on one subunit to be incorporated into acetyl~~-~~CoA at the A-cluster on the other subunit.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12386327}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12386327 is the PubMed ID number.

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==About this Structure==

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[[Category: Substrate tunnel]]

[[Category: Wood-ljundahl pathway]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ 3 01:11:18 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:06:41 2008''

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-[[Image:1mjg.gif|left|200px]]
+{{Seed}}
+[[Image:1mjg.png|left|200px]]
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 {{STRUCTURE_1mjg|  PDB=1mjg  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)'''
+===CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM)===
-==Overview==
+<!--
-A metallocofactor containing iron, sulfur, copper, and nickel has been discovered in the enzyme carbon monoxide dehydrogenase/acetyl-CoA (coenzyme A) synthase from Moorella thermoacetica (f. Clostridium thermoaceticum). Our structure at 2.2 angstrom resolution reveals that the cofactor responsible for the assembly of acetyl-CoA contains a [Fe4S4] cubane bridged to a copper-nickel binuclear site. The presence of these three metals together in one cluster was unanticipated and suggests a newly discovered role for copper in biology. The different active sites of this bifunctional enzyme complex are connected via a channel, 138 angstroms long, that provides a conduit for carbon monoxide generated at the C-cluster on one subunit to be incorporated into acetyl-CoA at the A-cluster on the other subunit.
+The line below this paragraph, {{ABSTRACT_PUBMED_12386327}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12386327 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12386327}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Substrate tunnel]]
 [[Category: Wood-ljundahl pathway]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:11:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:06:41 2008''