1mk3: Difference between revisions

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[[Image:1mk3.gif|left|200px]]
{{Seed}}
[[Image:1mk3.png|left|200px]]


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{{STRUCTURE_1mk3|  PDB=1mk3  |  SCENE=  }}  
{{STRUCTURE_1mk3|  PDB=1mk3  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN'''
===SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN===




==Overview==
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The structure of human BCL-w, an anti-apoptotic member of the BCL-2 family, was determined by triple-resonance NMR spectroscopy and molecular modeling. Introduction of a single amino acid substitution (P117V) significantly improved the quality of the NMR spectra obtained. The cytosolic domain of BCL-w consists of 8 alpha-helices, which adopt a fold similar to that of BCL-xL, BCL-2, and BAX proteins. Pairwise root meant square deviation values were less than 3 A for backbone atoms of structurally equivalent regions. Interestingly, the C-terminal helix alpha8 of BCL-w folds into the BH3-binding hydrophobic cleft of the protein, in a fashion similar to the C-terminal transmembrane helix of BAX. A peptide corresponding to the BH3 region of the pro-apoptotic protein, BID, could displace helix alpha8 from the BCL-w cleft, resulting in helix unfolding. Deletion of helix alpha8 increased binding affinities of BCL-w for BAK and BID BH3-peptides, indicating that this helix competes for peptide binding to the hydrophobic cleft. These results suggest that although the cytosolic domain of BCL-w exhibits an overall structure similar to that of BCL-xL and BCL-2, the unique organization of its C-terminal helix may modulate BCL-w interactions with pro-apoptotic binding partners.
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{{ABSTRACT_PUBMED_12651847}}


==About this Structure==
==About this Structure==
1MK3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK3 OCA].  
1MK3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK3 OCA].  


==Reference==
==Reference==
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[[Category: Apoptoti]]
[[Category: Apoptoti]]
[[Category: Bcl-w protein]]
[[Category: Bcl-w protein]]
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Revision as of 21:09, 2 July 2008

File:1mk3.png

Template:STRUCTURE 1mk3

SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN

Template:ABSTRACT PUBMED 12651847

About this Structure

1MK3 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix., Denisov AY, Madiraju MS, Chen G, Khadir A, Beauparlant P, Attardo G, Shore GC, Gehring K, J Biol Chem. 2003 Jun 6;278(23):21124-8. Epub 2003 Mar 21. PMID:12651847

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