1mq0: Difference between revisions
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New page: left|200px<br /> <applet load="1mq0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mq0, resolution 2.40Å" /> '''Crystal Structure o... |
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[[Image:1mq0.gif|left|200px]]<br /> | [[Image:1mq0.gif|left|200px]]<br /><applet load="1mq0" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1mq0" size=" | |||
caption="1mq0, resolution 2.40Å" /> | caption="1mq0, resolution 2.40Å" /> | ||
'''Crystal Structure of Human Cytidine Deaminase'''<br /> | '''Crystal Structure of Human Cytidine Deaminase'''<br /> | ||
==Overview== | ==Overview== | ||
Human cytidine deaminase (CDA) is an enzyme prominent for its role in | Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1MQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and BRD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] Full crystallographic information is available from [http:// | 1MQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=BRD:'>BRD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ0 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chung, S | [[Category: Chung, S J.]] | ||
[[Category: Fromme, J | [[Category: Fromme, J C.]] | ||
[[Category: Verdine, G | [[Category: Verdine, G L.]] | ||
[[Category: BRD]] | [[Category: BRD]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:47 2008'' | ||
