1mmb: Difference between revisions

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[[Image:1mmb.~~gif~~|left|200px]]

[[Image:1mmb.png|left|200px]]

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~~'''~~COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8~~'''~~

===COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8===

~~==Overview==~~

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~~Matrix metalloproteinases are a family of zinc endopeptidases involved in tissue remodeling. They have been implicated in various disease processes including metastasis~~, ~~joint destruction~~, ~~and neurodegeneration. Human neutrophil collagenase (HNC, MMP-8) represents one of~~ the ~~three "interstitial" collagenases that cleave triple-helical collagens types I, II, and III. Its 163-residue catalytic domain~~ (~~Met80 to Gly242) has been expressed in Escherichia coli and crystallized~~ as ~~a noncovalent complex with the hydroxamate inhibitor batimastat~~. ~~The crystal structure, refined to 2~~.~~1 A~~, ~~demonstrates that batimastat binds to the S1-S2' sites and coordinates to the catalytic zinc in a bidentate manner via the hydroxyl and carbonyl oxygens of~~ the ~~hydroxamate group~~. ~~The batimastat~~-~~collagenase complex is described in detail, and the activities of batimastat analogues are discussed in the light of the protein~~-~~inhibitor interactions revealed by the crystallography studies.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7577999}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7577999 is the PubMed ID number.

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==About this Structure==

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[[Category: Metalloprotease]]

[[Category: Metzincin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ 3 01:24:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:20:35 2008''

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-[[Image:1mmb.gif|left|200px]]
+{{Seed}}
+[[Image:1mmb.png|left|200px]]
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 {{STRUCTURE_1mmb|  PDB=1mmb  |  SCENE=  }}
-'''COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8'''
+===COMPLEX OF BB94 WITH THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE-8===
-==Overview==
+<!--
-Matrix metalloproteinases are a family of zinc endopeptidases involved in tissue remodeling. They have been implicated in various disease processes including metastasis, joint destruction, and neurodegeneration. Human neutrophil collagenase (HNC, MMP-8) represents one of the three "interstitial" collagenases that cleave triple-helical collagens types I, II, and III. Its 163-residue catalytic domain (Met80 to Gly242) has been expressed in Escherichia coli and crystallized as a noncovalent complex with the hydroxamate inhibitor batimastat. The crystal structure, refined to 2.1 A, demonstrates that batimastat binds to the S1-S2' sites and coordinates to the catalytic zinc in a bidentate manner via the hydroxyl and carbonyl oxygens of the hydroxamate group. The batimastat-collagenase complex is described in detail, and the activities of batimastat analogues are discussed in the light of the protein-inhibitor interactions revealed by the crystallography studies.
+The line below this paragraph, {{ABSTRACT_PUBMED_7577999}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7577999 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7577999}}
 ==About this Structure==
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 [[Category: Metalloprotease]]
 [[Category: Metzincin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:24:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:20:35 2008''