1mmj: Difference between revisions

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[[Image:1mmj.gif|left|200px]]
{{Seed}}
[[Image:1mmj.png|left|200px]]


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{{STRUCTURE_1mmj|  PDB=1mmj  |  SCENE=  }}  
{{STRUCTURE_1mmj|  PDB=1mmj  |  SCENE=  }}  


'''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''
===Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706===




==Overview==
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The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_12467609}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12467609}}


==About this Structure==
==About this Structure==
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[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
[[Category: Chymotrypsin family]]
[[Category: Chymotrypsin family]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:25:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:23:03 2008''
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