8q5h: Difference between revisions
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==Human KMN network (outer kinetochore)== | |||
<StructureSection load='8q5h' size='340' side='right'caption='[[8q5h]], [[Resolution|resolution]] 4.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8q5h]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q5H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q5h OCA], [https://pdbe.org/8q5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q5h RCSB], [https://www.ebi.ac.uk/pdbsum/8q5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q5h ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPC24_HUMAN SPC24_HUMAN] Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).<ref>PMID:14738735</ref> <ref>PMID:23085020</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Musacchio A]] | |||
[[Category: Polley S]] | |||
[[Category: Raisch T]] | |||
[[Category: Raunser S]] | |||
[[Category: Vetter I]] | |||
Revision as of 07:20, 14 February 2024
Human KMN network (outer kinetochore)
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