1mn8: Difference between revisions

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[[Image:1mn8.~~gif~~|left|200px]]

[[Image:1mn8.png|left|200px]]

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~~'''~~Structure of Moloney Murine Leukaemia Virus Matrix Protein~~'''~~

===Structure of Moloney Murine Leukaemia Virus Matrix Protein===

~~==Overview==~~

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~~Matrix proteins associated with~~ the ~~viral membrane are important in~~ the ~~formation of the viral particle and in virus maturation~~. ~~The 1~~.~~0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV~~) ~~matrix protein reveals the conserved topology of other retroviral matrix proteins~~, ~~despite undetectable sequence similarity. The N terminus (normally myristylated)~~ is ~~exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in~~ the ~~asymmetric unit make varied contacts~~. ~~The M~~-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.

The line below this paragraph, {{ABSTRACT_PUBMED_12467570}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12467570 is the PubMed ID number.

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==About this Structure==

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[[Category: Stuart, D.]]

[[Category: Helical bundle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ 3 01:26:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:26:38 2008''

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-[[Image:1mn8.gif|left|200px]]
+{{Seed}}
+[[Image:1mn8.png|left|200px]]
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 {{STRUCTURE_1mn8|  PDB=1mn8  |  SCENE=  }}
-'''Structure of Moloney Murine Leukaemia Virus Matrix Protein'''
+===Structure of Moloney Murine Leukaemia Virus Matrix Protein===
-==Overview==
+<!--
-Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_12467570}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12467570 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12467570}}
 ==About this Structure==
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 [[Category: Stuart, D.]]
 [[Category: Helical bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:26:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:26:38 2008''