1mr1: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1mr1.gif|left|200px]]
{{Seed}}
[[Image:1mr1.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mr1|  PDB=1mr1  |  SCENE=  }}  
{{STRUCTURE_1mr1|  PDB=1mr1  |  SCENE=  }}  


'''Crystal Structure of a Smad4-Ski Complex'''
===Crystal Structure of a Smad4-Ski Complex===




==Overview==
<!--
The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.
The line below this paragraph, {{ABSTRACT_PUBMED_12419246}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12419246 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12419246}}


==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Smad]]
[[Category: Smad]]
[[Category: Tgf-b signaling]]
[[Category: Tgf-b signaling]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:37:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:37:18 2008''
Retrieved from "https://proteopedia.org/1mr1"