1mrp: Difference between revisions

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[[Image:1mrp.jpg|left|200px]]
{{Seed}}
[[Image:1mrp.png|left|200px]]


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{{STRUCTURE_1mrp|  PDB=1mrp  |  SCENE=  }}  
{{STRUCTURE_1mrp|  PDB=1mrp  |  SCENE=  }}  


'''FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE'''
===FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE===




==Overview==
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The first crystal structure of the iron-transporter ferric ion-binding protein from Haemophilus influenzae (hFBP), at 1.6 A resolution, reveals the structural basis for iron uptake and transport required by several important bacterial pathogens. Paradoxically, although hFBP belongs to a protein superfamily which includes human transferrin, iron binding in hFBP and transferrin appears to have developed independently by convergent evolution. Structural comparison of hFBP with other prokaryotic periplasmic transport proteins and the eukaryotic transferrins suggests that these proteins are related by divergent evolution from an anion-binding common ancestor, not from an iron-binding ancestor. The iron binding site of hFBP incorporates a water and an exogenous phosphate ion as iron ligands and exhibits nearly ideal octahedral metal coordination. FBP is highly conserved, required for virulence, and is a nodal point for free iron uptake in several Gram-negative pathogenic bacteria, thus providing a potential target for broad-spectrum antibacterial drug design against human pathogens such as H. influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis.
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{{ABSTRACT_PUBMED_9360608}}


==About this Structure==
==About this Structure==
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[[Category: Periplasmic binding protein]]
[[Category: Periplasmic binding protein]]
[[Category: Transferrin superfamily]]
[[Category: Transferrin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:34:19 2008''

Revision as of 11:34, 28 July 2008

File:1mrp.png

Template:STRUCTURE 1mrp

FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE

Template:ABSTRACT PUBMED 9360608

About this Structure

1MRP is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily., Bruns CM, Nowalk AJ, Arvai AS, McTigue MA, Vaughan KG, Mietzner TA, McRee DE, Nat Struct Biol. 1997 Nov;4(11):919-24. PMID:9360608

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