1n26: Difference between revisions
New page: left|200px<br /> <applet load="1n26" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n26, resolution 2.4Å" /> '''Crystal Structure of... |
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[[Image:1n26.gif|left|200px]]<br /> | [[Image:1n26.gif|left|200px]]<br /><applet load="1n26" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1n26, resolution 2.4Å" /> | caption="1n26, resolution 2.4Å" /> | ||
'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''<br /> | '''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''<br /> | ||
==Overview== | ==Overview== | ||
Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in | Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex. | ||
==About this Structure== | ==About this Structure== | ||
1N26 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, SO4 and CYS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1N26 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CYS:'>CYS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N26 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Branson, K | [[Category: Branson, K M.]] | ||
[[Category: Donkelaar, A | [[Category: Donkelaar, A van.]] | ||
[[Category: Hall, N | [[Category: Hall, N E.]] | ||
[[Category: Ivancic, N.]] | [[Category: Ivancic, N.]] | ||
[[Category: Ji, H.]] | [[Category: Ji, H.]] | ||
[[Category: Lou, M | [[Category: Lou, M Z.]] | ||
[[Category: Moritz, R | [[Category: Moritz, R L.]] | ||
[[Category: Simpson, R | [[Category: Simpson, R J.]] | ||
[[Category: Varghese, J | [[Category: Varghese, J N.]] | ||
[[Category: CYS]] | [[Category: CYS]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:29 2008'' | ||
Revision as of 12:01, 21 February 2008
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Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain
Overview
Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex.
About this Structure
1N26 is a Single protein structure of sequence from Homo sapiens with NAG, SO4 and CYS as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain., Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ, Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:12461182
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