1mru: Difference between revisions

Line 1:

[[Image:1mru.~~gif~~|left|200px]]

[[Image:1mru.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.~~'''~~

===Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.===

~~==Overview==~~

<!--

~~A family of eukaryotic-like Ser/Thr protein kinases occurs in bacteria~~, ~~but little is known about~~ the ~~structures and functions of these proteins~~. ~~Here we characterize PknB, a transmembrane signaling kinase from Mycobacterium tuberculosis~~. ~~The intracellular PknB kinase domain is active autonomously~~, ~~and the active enzyme~~ is ~~phosphorylated on residues homologous to regulatory phospho-acceptors in eukaryotic Ser/Thr kinases. The crystal structure of~~ the ~~PknB kinase domain in complex with an ATP analog reveals the active conformation~~. ~~The predicted fold of the PknB extracellular domain matches the proposed targeting domain of penicillin~~-~~binding protein 2x. The structural and chemical similarities of PknB to metazoan homologs support a universal activation mechanism of Ser/Thr protein kinases in prokaryotes and eukaryotes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12548283}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12548283 is the PubMed ID number.

-->

==About this Structure==

Line 35:

Line 39:

[[Category: Tb structural genomics consortium]]

[[Category: Tbsgc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:38:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:47:47 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1mru.gif|left|200px]]
+{{Seed}}
+[[Image:1mru.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1mru|  PDB=1mru  |  SCENE=  }}
-'''Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.'''
+===Intracellular Ser/Thr protein kinase domain of Mycobacterium tuberculosis PknB.===
-==Overview==
+<!--
-A family of eukaryotic-like Ser/Thr protein kinases occurs in bacteria, but little is known about the structures and functions of these proteins. Here we characterize PknB, a transmembrane signaling kinase from Mycobacterium tuberculosis. The intracellular PknB kinase domain is active autonomously, and the active enzyme is phosphorylated on residues homologous to regulatory phospho-acceptors in eukaryotic Ser/Thr kinases. The crystal structure of the PknB kinase domain in complex with an ATP analog reveals the active conformation. The predicted fold of the PknB extracellular domain matches the proposed targeting domain of penicillin-binding protein 2x. The structural and chemical similarities of PknB to metazoan homologs support a universal activation mechanism of Ser/Thr protein kinases in prokaryotes and eukaryotes.
+The line below this paragraph, {{ABSTRACT_PUBMED_12548283}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12548283 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12548283}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Tb structural genomics consortium]]
 [[Category: Tbsgc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:38:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:47:47 2008''