1mtn: Difference between revisions

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[[Image:1mtn.gif|left|200px]]
{{Seed}}
[[Image:1mtn.png|left|200px]]


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{{STRUCTURE_1mtn|  PDB=1mtn  |  SCENE=  }}  
{{STRUCTURE_1mtn|  PDB=1mtn  |  SCENE=  }}  


'''BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION'''
===BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION===




==Overview==
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The crystal structure of bovine alpha-chymotrypsin (alpha-CHT) in complex with the bovine basic pancreatic trypsin inhibitor (BPTI) has been solved and refined at 2.8 A resolution (R-factor = 0.18). The proteinase:inhibitor complex forms a compact dimer (two alpha-CHT and two BPTI molecules), which may be stabilized by surface-bound sulphate ions, in the crystalline state. Each BPTI molecule, at opposite ends, is contacting both proteinase molecules in the dimer, through the reactive site loop and through residues next to the inhibitor's C-terminal region. Specific recognition between alpha-CHT and BPTI occurs at the (re)active site interface according to structural rules inferred from the analysis of homologous serine proteinase:inhibitor complexes. Lys15, the P1 residue of BPTI, however, does not occupy the alpha-CHT S1 specificity pocket, being hydrogen bonded to backbone atoms of the enzyme surface residues Gly216 and Ser217.
The line below this paragraph, {{ABSTRACT_PUBMED_9179777}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9179777 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9179777}}


==About this Structure==
==About this Structure==
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[[Category: Serine]]
[[Category: Serine]]
[[Category: Trypsin]]
[[Category: Trypsin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:42:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:13:19 2008''

Revision as of 12:13, 28 July 2008

File:1mtn.png

Template:STRUCTURE 1mtn

BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION

Template:ABSTRACT PUBMED 9179777

About this Structure

1MTN is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the bovine alpha-chymotrypsin:Kunitz inhibitor complex. An example of multiple protein:protein recognition sites., Capasso C, Rizzi M, Menegatti E, Ascenzi P, Bolognesi M, J Mol Recognit. 1997 Jan-Feb;10(1):26-35. PMID:9179777

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