1mtl: Difference between revisions

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[[Image:1mtl.jpg|left|200px]]
{{Seed}}
[[Image:1mtl.png|left|200px]]


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{{STRUCTURE_1mtl|  PDB=1mtl  |  SCENE=  }}  
{{STRUCTURE_1mtl|  PDB=1mtl  |  SCENE=  }}  


'''Non-productive MUG-DNA complex'''
===Non-productive MUG-DNA complex===




==Overview==
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Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.
The line below this paragraph, {{ABSTRACT_PUBMED_9699633}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9699633 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9699633}}


==About this Structure==
==About this Structure==
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[[Category: Inter-strand]]
[[Category: Inter-strand]]
[[Category: Non-productive]]
[[Category: Non-productive]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:42:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:21:09 2008''
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